I think in this and the "To serve man" thread Da Blob is trying to discuses the ineffable thing that's the difference between being fed, clothed, educated, etc, and being "cared for" in a way that supports emotional wellbeing.
*ponders for a while*
Say there's children growing up in the Aperture science facility (y'know from the portal games) now they're orphans (clones or whatever) and they've never met another human being, heck they've never even seen dirt or the sky, their world is what Glados deems it should be.
In this entirely artificial environment devoid of human interaction the natural assumption would be that they would be quite emotionally unwell, but I think that depends upon how they're treated, specifically their perceptions of Glados based upon how she treats them. If their treatment suggests that Glados has an interest in their wellbeing they'll feel happy and secure whereas if they think she dislikes them for some reason or is only using them as expendable test subjects (as "objects" in Da Blob's terminology) they'll be insecure and fearful.
I think the actual qualities of the of the parental figure are irrelevant, as long as it behaves in a manner that leads the children in question to believe it cares about them then they'll have that subconscious reassurance required for psychological well being, indeed even if Glados has them performing difficult/dangerous trials as long as she's encouraging them they'll feel loved by her and continue to love her in return.
The robotic hand mentioned earlier could be a cold, hard, iron black industrial gripper, but as long as it's gentle and attentive the child will become accepting of it, especially if this is all the child has ever known, indeed if that child is later adopted by human parents it may find their soft, warm hands incredibly disturbing, which seems strange to us but remember we have the latter associative bias, of course it seems strange to us, as every bit as strange as we would seem to the child with a different associative bias.