Just to give you an idea of CO, at least Denver, it took me about 2-3 months to find an entry level job when I moved here a year ago, and that was with 2-3 apps going out a day... well, that might be a little exaggerated, but I tried to make that my goal :P (I totally don't have that much motivation >.<)
I dunno, the living expense is a ton more than I was expecting, but then, it's cheaper than East / West coast, just definitely more expensive than SD, by quite a lot. I'm making about 3 dollars more an hour, and coming home with about 100 dollars less per paycheck. It sucks.
My sisters husband was just laid off a few months ago, and he's not really been able to find a job, but he also hasn't been looking terribly hard. Denver... didn't have as much to do as I was thinking it might, but it's really nice having the mountains nearby. I like nature / hiking though, so it works.
Agreed on the comment about boulder, it's expensive, and snobby... the people there are like... fake, I suppose, is the best way to put it.
Zero, you're in CO? Let's hang out ^_^ Or something. haha.
It seems like loveland / fort collins is a decent area, but I don't know much about it overall. FoCo is definitely a college town, but from what I've heard loveland is a little nicer... they're not far apart though, so living in one is kind of like living in the other.