'What makes you happy' defined as simple, free, and resourceful activities that promote a better state of mind.
So in that case.
What happens if you separate from 'what makes you happy'?
Your well-being will suffer.
I'm going to guess that your mind will take it as a threat. In which case, irritability, and hostility will ensue, as you fight angrily to get back to peace of mind.
If it continues, you will either go bat-shit crazy, or you may reach deeper within yourself to keep yourself together, everyday. Keeping hope that some day you will reach the other side of hell if you just keep walking.